Dawson R B, Hershey R T, Myers C S, Zuck T F
Transfusion. 1980 Jan-Feb;20(1):110-3. doi: 10.1046/j.1537-2995.1980.20180125025.x.
Because there may be inadequate dextrose in the newly licensed CPD-adenine for five or six weeks storage of high hematocrit red blood cells, this laboratory has examined some alternate sugars for their ability to maintain red blood cell metabolism during storage. In the current study, dextrose and fructose were studied as model or prototype nutrients. A third six carbon monosacharide, galactose, three dissacharides, lactose, maltose, and sucrose were studied in the same experiment. Of these, fructose best maintained ATP and 2,3-DPG during the fourth to sixth week of whole blood storage at 4 C. Dextrose was next best during this time and was nearly equivalent to fructose in the first three weeks of storage. Galactose and maltose both maintained ATP and 2,3-DPG, but not nearly so well as did fructose and dextrose. Sucrose and lactose were associated with the most rapid deterioration of ATP and DPG levels and they failed to maintain the progressive fall in pH which is usually associated with continuing, useful metabolism.
由于新获批的CPD-腺嘌呤中可能没有足够的葡萄糖用于高血细胞比容红细胞储存五到六周，本实验室研究了一些替代糖类在储存期间维持红细胞代谢的能力。在当前研究中，葡萄糖和果糖作为典型或原型营养物质进行了研究。在同一实验中还研究了第三种六碳单糖半乳糖、三种双糖乳糖、麦芽糖和蔗糖。其中，果糖在4℃全血储存的第四至六周期间能最好地维持ATP和2,3-DPG水平。在此期间葡萄糖次之，且在储存的前三周与果糖几乎相当。半乳糖和麦芽糖都能维持ATP和2,3-DPG水平，但远不如果糖和葡萄糖。蔗糖和乳糖与ATP和DPG水平的最快速下降有关，并且它们未能维持通常与持续有效代谢相关的pH值逐渐下降。
