Dawson R B, Levine Z, Zuck T, Hershey R T, Myers C
Transfusion. 1978 May-Jun;18(3):347-52. doi: 10.1046/j.1537-2995.1978.18378205145.x.
Mannose and fructose as well as glucose have been shown to be effective for maintaining ATP and thus viability of stored red blood cells. Normal 2,3-DPG levels are desirable in stored red blood cells to provide the needed oxygen transport upon transfusion. ATP levels in sotred concentrated red blood cells in the new preservative, CPD-adenine (citrate-phosphate-dextrose-adenine) become critically low in the 5th week. In this study two hexoses and two pentoses are compared with dextrose in their ability to maintain ATP and 2,3-DPG. ATP levels were best maintained by fructose, then dextrose and mannose. ATP levels had fallen to critically low levels by four weeks with ribose and xylose. Red blood cell 2,3-DPG concentrations were also maintained by hexoses, with mannose being best, dextrose and fructose being similar. When ribose was used in addition to dextrose in CPD-adenine, ATP maintenance was improved and under the same conditions xylose improved 2,3-DPG maintenance. Fructose and mannose may be as useful as dextrose in citrate-phosphate preservatives for maintaining ATP and 2,3-DPG levels. Also, ribose and xylose may help the maintenance of ATP and 2,3-DPG, respectively, in CPD-adenine.
已证明甘露糖、果糖以及葡萄糖对于维持三磷酸腺苷（ATP）水平进而维持储存红细胞的活力是有效的。储存红细胞中保持正常的2,3-二磷酸甘油酸（2,3-DPG）水平，有助于输血时进行所需的氧气运输。在新型保存液CPD-腺嘌呤（枸橼酸盐-磷酸盐-葡萄糖-腺嘌呤）中储存的浓缩红细胞，其ATP水平在第5周时会极低。在本研究中，将两种己糖和两种戊糖与葡萄糖在维持ATP和2,3-DPG的能力方面进行了比较。果糖维持ATP水平的效果最佳，其次是葡萄糖和甘露糖。使用核糖和木糖时，红细胞的ATP水平在四周时就降至极低水平。己糖也能维持红细胞中2,3-DPG的浓度，其中甘露糖的效果最佳，葡萄糖和果糖的效果相近。在CPD-腺嘌呤保存液中，当在葡萄糖基础上添加核糖时，ATP的维持情况得到改善；在相同条件下，添加木糖则改善了2,3-DPG的维持情况。在枸橼酸盐-磷酸盐保存液中，果糖和甘露糖在维持ATP和2,3-DPG水平方面可能与葡萄糖同样有效。此外，核糖和木糖可能分别有助于在CPD-腺嘌呤中维持ATP和2,3-DPG水平。
