Ness P M, Perkins H A
Transfusion. 1980 Jan-Feb;20(1):93-6. doi: 10.1046/j.1537-2995.1980.20180125050.x.
Very little has been published to indicate the quantity of fibrinogen in cryoprecipitates. We assayed 88 preparations from five blood banks for factor VIII(AHF) and fibrinogen to assess whether the AHF assay can predict the fibrinogen content. Cryoprecipitate was considered to be consistent with FDA standards with 80 units of factor VIII/bag (40% yield from 200 ml plasma). Fibrinogen was considered adequate if 200 mg were recovered (40% yield, 200 ml plasma, normal range 150--350 mg/dl). The mean AHF was 145 units/bag and fibrinogen. In 64/88 bags, the fibrinogen and AHF were concordant, but in 24/88 bags the results were discordant. Although it appears safe to conclude that a bag of cryoprecipitate will average 250 mg fibrinogen, adequate control may require separate assays for fibrinogen.
关于冷沉淀中纤维蛋白原含量的报道非常少。我们对来自五个血库的88份制品进行了因子VIII（抗血友病因子）和纤维蛋白原检测，以评估抗血友病因子检测能否预测纤维蛋白原含量。冷沉淀若每袋含80单位因子VIII（从200毫升血浆中获得40%的回收率）则被认为符合美国食品药品监督管理局标准。若回收200毫克纤维蛋白原（40%的回收率，200毫升血浆，正常范围150 - 350毫克/分升），则认为纤维蛋白原含量充足。因子VIII平均含量为每袋145单位，纤维蛋白原也是如此。在88袋制品中，64袋的纤维蛋白原和因子VIII结果一致，但24袋结果不一致。虽然可以有把握地得出一袋冷沉淀平均含250毫克纤维蛋白原的结论，但充分的质量控制可能需要对纤维蛋白原进行单独检测。
