Piva F, Borrell J, Limonta P, Gavazzi G, Martini L
Acta Endocrinol (Copenh). 1980 Jan;93(1):1-6. doi: 10.1530/acta.0.0930001.
Adult female rats castrated 4 weeks before were implanted bilaterially into the basomedial area of the amygdala with drugs known to mimic or to counteract the actions of acetylcholine. The animals were sacrificed at different time intervals after the implantation of the different compounds, and serum levels of LH and FSH were measured by radioimmunoassay. The data obtained indicate that the intra-amygdalar implantation of the muscarinic blocker atropine induces a significant increase of the release of LH without altering FSH secretion. The implantation of two cholinomimetic drugs, pilocarpine, an almost pure muscarinic agonist, and carbachol, which possesses both muscarinic and nicotinic properties, exerted an inhibitory effect only on LH release. On the contrary, the intra-amygdala placement of the nicotinic blocker mecamylamine was followed by an increase of FSH with no changes in LH. These observations may suggest that cholinergic signals reaching the amydgala may be of some relevance in the mechanisms controlling gonadotrophine secretion. Muscarinic receptors seem to play an inhibitory role in the regulation of LH secretion, while nicotinic receptors seem to modulate in an inhibitory way FSH release.
四周前接受双侧卵巢切除的成年雌性大鼠，被双侧植入已知可模拟或抵消乙酰胆碱作用的药物至杏仁核基底内侧区域。在植入不同化合物后的不同时间间隔处死动物，并用放射免疫分析法测定血清促黄体生成素（LH）和促卵泡生成素（FSH）水平。所得数据表明，向杏仁核内植入毒蕈碱受体阻滞剂阿托品可显著增加LH的释放，而不改变FSH的分泌。植入两种拟胆碱药物，几乎为纯毒蕈碱激动剂的毛果芸香碱和兼具毒蕈碱和烟碱特性的卡巴胆碱，仅对LH释放产生抑制作用。相反，向杏仁核内植入烟碱受体阻滞剂美加明后，FSH增加而LH无变化。这些观察结果可能提示，到达杏仁核的胆碱能信号在控制促性腺激素分泌的机制中可能具有一定相关性。毒蕈碱受体似乎在LH分泌的调节中起抑制作用，而烟碱受体似乎以抑制方式调节FSH释放。
