Borrell J, Piva F, Martini L
Acta Endocrinol (Copenh). 1979 Mar;90(3):385-93. doi: 10.1530/acta.0.0900385.
Drugs able to mimic or to antagonize the action of catecholamines have been implanted bilaterally into the basomedial region of the amygdala of adult castrated female rats. The animals were killed at different intervals after the implantation of the different drugs, and serum levels of LH and FSH were measured by radioimmunoassay. The results have shown that the intra-amygdalar implantation of the alpha-adrenergic blocker phenoxybenzamine induces a significant increase of the release both of LH and FSH. The implantation of the beta-adrenergic blocker propranolol brings about a rise of LH only. The dopamine receptor blocker pimozide stimulates the release of LH and exerts a biphasic effect (stimulation followed by inhibition) of FSH secretion. The alpha-receptor stimulant clonidine and the dopaminergic drug 2-Br-alpha-ergocryptine were without significant effects. From these observations it is suggested that the adrenergic signals reaching the basomedial area of the amygdala (possibly from the brain stem) may be involved in the modulation of gonadotrophin secretion.
已将能够模拟或拮抗儿茶酚胺作用的药物双侧植入成年去势雌性大鼠杏仁核的基底内侧区域。在植入不同药物后的不同时间间隔处死动物，并通过放射免疫测定法测量血清促黄体生成素（LH）和促卵泡生成素（FSH）水平。结果表明，向杏仁核内植入α-肾上腺素能阻滞剂酚苄明会导致LH和FSH的释放均显著增加。植入β-肾上腺素能阻滞剂普萘洛尔仅使LH升高。多巴胺受体阻滞剂匹莫齐特刺激LH的释放，并对FSH分泌产生双相作用（先刺激后抑制）。α-受体兴奋剂可乐定和多巴胺能药物2-溴-α-麦角隐亭无显著作用。从这些观察结果推测，到达杏仁核基底内侧区域（可能来自脑干）的肾上腺素能信号可能参与促性腺激素分泌的调节。
