Hwang D W, Godke R A, Rings R W
Lipids. 1980 Aug;15(8):597-600. doi: 10.1007/BF02534186.
Levels of prostaglandin (PG) precursor acids, and PGE2, PGF2 alpha and TXB2 in sera of adult animals (5/species) were determined by gas chromatography and radioimmunoassay, respectively. The level of arachidonic acid in horse serum lipids was the lowest (0.61 +/- 0.03%), and that in dog serum lipids was the highest (18.1 +/- 1.8%). Bovine serum lipids contained considerable amounts of 20:3 omega 6 (precursor of monoene PG) and 20:5 omega 3 (precursor of triene PG) in addition to arachidonic acid. Thromboxane B2 was not the major species of endoperoxide metabolite synthesized by platelets from arachidonic acid in male ruminants and pig. The concentration of TXB2 in the serum of the lactating cow was more than 50 times greater than that of ovariectomized cows or of bulls. Although TXB2 was the major species of endoperoxide metabolite synthesized by human platelets, its serum concentration was much lower than that of nonruminant animals except the pig. These results showed that there were considerable variations in levels of PG and their precursors among various species of animals. The species variation in PG and TXB2 concentrations was not simply attributed to the differences in platelet concentration blood.
分别采用气相色谱法和放射免疫分析法测定了成年动物（5个物种）血清中前列腺素（PG）前体酸、PGE2、PGF2α和TXB2的水平。马血清脂质中花生四烯酸的水平最低（0.61±0.03%），犬血清脂质中花生四烯酸的水平最高（18.1±1.8%）。除花生四烯酸外，牛血清脂质还含有大量的20:3ω6（单烯PG的前体）和20:5ω3（三烯PG的前体）。在雄性反刍动物和猪中，血栓素B2不是血小板由花生四烯酸合成的主要内过氧化物代谢产物。泌乳奶牛血清中TXB2的浓度比去卵巢奶牛或公牛血清中TXB2的浓度高50倍以上。虽然TXB2是人类血小板合成的主要内过氧化物代谢产物，但其血清浓度比除猪以外的非反刍动物低得多。这些结果表明，不同动物物种之间PG及其前体的水平存在显著差异。PG和TXB2浓度的物种差异不能简单地归因于血液中血小板浓度的差异。
