Davidson B J, Riggs B L, Coulam C B, Toft D O
Am J Obstet Gynecol. 1980 Feb 15;136(4):430-3. doi: 10.1016/0002-9378(80)90666-3.
Although all postmenopausal women are relatively estrogen-deficient, osteoporosis develops in only some of them. This could be related to a greater-than-normal degree of postmenopausal failure in sex hormone production or to a decrease in biologic effect at target tissue sites. We compared the concentration of sex steroids in serum and the concentration of cytosolic estrogen receptors in one target tissue (obtained by biopsy of the uterine cervix) in 18 women with postmenopausal osteoporosis and in 18 age-matched postmenopausal control subjects. Serum androstenedione and estrone were not significantly lower and serum estradiol was only marginally lower in the osteoporotic patients. Estrogen-receptor concentration in cervical tissue from both postmenopausal groups was not significantly different. We concluded that abnormalities of residual postmenopausal production of sex steroids and binding of sex steroids to cervical target tissue are not the major factors accounting for the decreased bone mass in women with postmenopausal osteoporosis.
尽管所有绝经后女性都相对缺乏雌激素，但只有部分女性会患骨质疏松症。这可能与绝经后性激素分泌功能比正常情况衰退得更严重有关，或者与靶组织部位的生物效应降低有关。我们比较了18例绝经后骨质疏松症女性和18例年龄匹配的绝经后对照受试者的血清中性类固醇浓度以及一个靶组织（通过宫颈活检获得）中的胞质雌激素受体浓度。骨质疏松症患者的血清雄烯二酮和雌酮没有显著降低，血清雌二醇仅略有降低。两个绝经后组宫颈组织中的雌激素受体浓度没有显著差异。我们得出结论，绝经后性激素残留分泌异常以及性激素与宫颈靶组织的结合不是绝经后骨质疏松症女性骨量减少的主要因素。
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