Mutch P B, Hurley L S
Am J Physiol. 1980 Jan;238(1):E26-31. doi: 10.1152/ajpendo.1980.238.1.E26.
The effect of dietary zinc deficiency during late pregnancy and lactation on the rat mammary gland was investigated by feeding female rats either a zinc-deficient diet (0.4 ppm Zn) or a zinc-sufficient diet (100 ppm Zn) ad libitum or restricted in amount. Zinc deficiency from day 0 of lactation specifically reduced the total RNA content of lactating mammary glands on day 14, but had no effect beyond that of food restriction on their total DNA content, Both RNA and DNA content of the mammary gland were decreased by reduced food intake. Zinc deficiency from day 14 of pregnancy to day 2 of lactation severely impaired parturition and prevented the normal rise in mammary gland RNA seen during lactogenesis in control animals. A shorter deficiency period, from day 18 of gestation, had no effect on mammary gland nucleic acids other than that due to inanition.
通过随意或限量喂养雌性大鼠缺锌饮食（锌含量为0.4 ppm）或充足锌饮食（锌含量为100 ppm），研究了妊娠后期和哺乳期饮食缺锌对大鼠乳腺的影响。从哺乳期第0天开始缺锌，会使第14天泌乳期乳腺的总RNA含量显著降低，但对其总DNA含量的影响不超过食物限制的影响。食物摄入量减少会使乳腺的RNA和DNA含量均降低。从妊娠第14天到哺乳期第2天缺锌，会严重损害分娩过程，并阻止对照动物在泌乳生成过程中出现的乳腺RNA正常增加。从妊娠第18天开始的较短缺锌期，除了因营养缺乏造成的影响外，对乳腺核酸没有影响。
