Pau M Y, Milner J A
J Nutr. 1982 Oct;112(10):1827-33. doi: 10.1093/jn/112.10.1827.
The effect of dietary arginine deficiency on rat mammary gland development was investigated in pregnant rats and ovariectomized nonpregnant rats. Consumption of an arginine-deficient diet from day 0 of pregnancy significantly reduced the total DNA and RNA content of the mammary gland by day 20. Pair-feeding studies revealed that reduced food intake associated with consumption of the arginine-deficient diet was not responsible for the altered nucleic acid content of the gland. Restriction of food intake by pair-feeding did reduce the wet weight of the mammary gland as well as its fat content when compared with ad libitum fed controls, but the degree of reduction did not fully account for the depressing effect on the wet weight and fat content observed when the arginine-deficient diet was fed. The ratio of RNA to DNA in the mammary tissues of rats fed the arginine-deficient diet indicated normal protein synthetic activity per cell. The extent of reduction in mammary nucleic acid content by arginine deficiency was similar for pregnant rats and ovariectomized nonpregnant rats treated with estrogen and progesterone. These studies show that dietary arginine is required for optimal mammary growth. The possible mechanism(s) by which arginine can modify mammary growth are discussed.
在怀孕大鼠和去卵巢未孕大鼠中研究了膳食精氨酸缺乏对大鼠乳腺发育的影响。从怀孕第0天开始食用精氨酸缺乏饮食，到第20天时，乳腺的总DNA和RNA含量显著降低。配对喂养研究表明，与食用精氨酸缺乏饮食相关的食物摄入量减少并不是腺体核酸含量改变的原因。与自由采食的对照组相比，通过配对喂养限制食物摄入量确实降低了乳腺的湿重及其脂肪含量，但降低程度并不能完全解释喂食精氨酸缺乏饮食时观察到的对湿重和脂肪含量的抑制作用。喂食精氨酸缺乏饮食的大鼠乳腺组织中RNA与DNA的比率表明每个细胞的蛋白质合成活性正常。怀孕大鼠以及用雌激素和孕酮处理的去卵巢未孕大鼠，精氨酸缺乏导致的乳腺核酸含量降低程度相似。这些研究表明，膳食精氨酸是乳腺最佳生长所必需的。讨论了精氨酸影响乳腺生长的可能机制。
