Pursley T V, Jacobson R R
Arch Dermatol. 1980 Feb;116(2):201-4.
A 38-year-old woman had diffuse, nonnodular, lepromatous leprosy and Lucio's phenomenon. Most cases of Lucio's phenomenon have been reported to have a leukocytoclastic vasculitis as the underlying pathologic abnormality. In this patient, however, the histologic picture of an early lesion of Lucio's phenomenon showed a milk, mononuclear cell infiltration, endothelial swelling, vascular thrombosis, and ischemic necrosis. Lepra bacilli were abundant around nerves and blood vessels, and many were noted in vascular walls and endothelium. Our findings raise the possibility that some cases of Lucio's phenomenon may be caused by vascular damage due to direct invasion of Mycobacterium leprae and not necessarily by leukocytoclastic vasculitis.
一名38岁女性患有弥漫性、非结节性瘤型麻风及卢西奥现象。据报道，大多数卢西奥现象病例的潜在病理异常为白细胞破碎性血管炎。然而，该患者卢西奥现象早期病变的组织学表现为乳糜样单核细胞浸润、内皮肿胀、血管血栓形成及缺血性坏死。神经和血管周围麻风杆菌丰富，在血管壁和内皮中也发现许多麻风杆菌。我们的研究结果提示，某些卢西奥现象病例可能是由麻风杆菌直接侵袭导致血管损伤引起的，而不一定是由白细胞破碎性血管炎所致。
