Mathias C G, Frick O L, Caldwell T M, Yunginger J W, Maibach H I
Arch Dermatol. 1980 Feb;116(2):209-12.
A woman with atopic dermatitis experienced anaphylactic episodes following intercourse with her husband, with subsequent exacerbations of her atopic dermatitis. Skin testing and an in vitro leukocyte histamine release assay established the diagnosis of immediate hypersensitivity to her husband's seminal fluid; delayed hypersensitivity to seminal fluid could not be demonstrated. Antigen was found in the seminal fluid of nonrelated men. Radioallergosorbent testing detected the presence of circulating IgE antibodies specific for seminal plasma protein. Immunotherapy with seminal plasma may have limited the severity of a subsequent reaction. Serum from the husband and nonrelated men also contained antigen that provoked histamine release from the patient's leukocytes in vitro. The antigen in serum was associated with the globulin fraction and had a temporal relationship to ejaculation, appearing within 12 hours of ejaculation and disappearing within four days.
一名患有特应性皮炎的女性在与丈夫性交后出现过敏反应，随后特应性皮炎病情加重。皮肤试验和体外白细胞组胺释放试验确诊对其丈夫精液立即过敏；未证实对精液存在迟发性过敏。在无关男性的精液中也发现了抗原。放射变应原吸附试验检测到循环中存在针对精浆蛋白的特异性IgE抗体。精浆免疫疗法可能减轻了后续反应的严重程度。丈夫和无关男性的血清中也含有能在体外刺激患者白细胞释放组胺的抗原。血清中的抗原与球蛋白部分有关，与射精存在时间关系，在射精后12小时内出现，4天内消失。
