McCubbin J A, Spratt J S
Arch Surg. 1980 Feb;115(2):224-8. doi: 10.1001/archsurg.1980.01380020090022.
The role of the no-touch technique was examined using retinoblastoma and primary choroidal malignant melanoma of the eye as a model. Choroidal invasion, tumor friability, and tumor vascularity are important factors that render these two tumors susceptible to metastasis secondary to intraorgan pressure increases. Animal studies on no-touch enucleation procedures show that increased intraocular pressure during enucleation decreases survival rates considerably providing the tumor has invaded the choroid but has not yet metastasized. This "critical stage" correlates well with earlier data on the no-touch technique studied in noneye models. In humans, standard enucleations create intraocular pressures measured up to 500 mm Hg. The no-touch technique is applicable to the therapy of retinoblastoma and primary choroidal malignant melanomas, but long-term clinical studies are needed to establish the true benefit.
以眼视网膜母细胞瘤和原发性脉络膜恶性黑色素瘤为模型，对非接触技术的作用进行了研究。脉络膜侵犯、肿瘤易碎性和肿瘤血管形成是使这两种肿瘤易因器官内压力增加而发生转移的重要因素。关于非接触眼球摘除术的动物研究表明，眼球摘除术中眼内压升高会显著降低生存率，前提是肿瘤已侵犯脉络膜但尚未转移。这个“关键阶段”与在非眼模型中研究的非接触技术的早期数据高度相关。在人类中，标准眼球摘除术可产生高达500毫米汞柱的眼内压。非接触技术适用于视网膜母细胞瘤和原发性脉络膜恶性黑色素瘤的治疗，但需要长期临床研究来确定其真正益处。
