半合成青霉素对新生儿血清结合胆红素的影响。
The effect of semisynthetic penicillins on the binding of bilirubin by neonatal serum.
作者信息
Friedman L A, Lewis P J
出版信息
Br J Clin Pharmacol. 1980 Jan;9(1):61-5. doi: 10.1111/j.1365-2125.1980.tb04798.x.
Abstract
- The effect of ampicillin, cloxacillin, flucloxacillin and sulphafurazole on bilirubin on bilirubin binding by pooled human umbilical cord serum and bovine serum albumin was studied in vitro using Sephadex gel filtration. 2. Sulphafurazole displaced bilirubin from binding; both cloxacillins displaced bilirubin from pooled cord serum but not bovine serum albumin. 4. No displacement of bilirubin by the cloxacillins from pooled cord serum could be detected at therapeutic plasma concentrations of these drugs. 5. Scatchard analysis of the interactions showed that displacement of bilirubin by these drugs occurred principally at the primary, high affinity, low capacity binding site.
摘要
- 采用葡聚糖凝胶过滤法在体外研究了氨苄西林、氯唑西林、氟氯西林和磺胺异恶唑对人脐血混合血清及牛血清白蛋白结合胆红素的影响。2. 磺胺异恶唑使胆红素脱离结合；两种氯唑西林均可使胆红素从脐血混合血清中脱离，但不能使胆红素从牛血清白蛋白中脱离。4. 在这些药物的治疗血浆浓度下，未检测到氯唑西林使胆红素从脐血混合血清中脱离。5. 相互作用的Scatchard分析表明，这些药物使胆红素脱离主要发生在一级高亲和力、低容量结合位点。
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