半合成青霉素对新生儿血清结合胆红素的影响。
The effect of semisynthetic penicillins on the binding of bilirubin by neonatal serum.
作者信息
Friedman L A, Lewis P J
出版信息
Br J Clin Pharmacol. 1980 Jan;9(1):61-5. doi: 10.1111/j.1365-2125.1980.tb04798.x.
Abstract
- The effect of ampicillin, cloxacillin, flucloxacillin and sulphafurazole on bilirubin on bilirubin binding by pooled human umbilical cord serum and bovine serum albumin was studied in vitro using Sephadex gel filtration. 2. Sulphafurazole displaced bilirubin from binding; both cloxacillins displaced bilirubin from pooled cord serum but not bovine serum albumin. 4. No displacement of bilirubin by the cloxacillins from pooled cord serum could be detected at therapeutic plasma concentrations of these drugs. 5. Scatchard analysis of the interactions showed that displacement of bilirubin by these drugs occurred principally at the primary, high affinity, low capacity binding site.
摘要
- 采用葡聚糖凝胶过滤法在体外研究了氨苄西林、氯唑西林、氟氯西林和磺胺异恶唑对人脐血混合血清及牛血清白蛋白结合胆红素的影响。2. 磺胺异恶唑使胆红素脱离结合；两种氯唑西林均可使胆红素从脐血混合血清中脱离，但不能使胆红素从牛血清白蛋白中脱离。4. 在这些药物的治疗血浆浓度下，未检测到氯唑西林使胆红素从脐血混合血清中脱离。5. 相互作用的Scatchard分析表明，这些药物使胆红素脱离主要发生在一级高亲和力、低容量结合位点。
相似文献
1
The effect of semisynthetic penicillins on the binding of bilirubin by neonatal serum.半合成青霉素对新生儿血清结合胆红素的影响。
Br J Clin Pharmacol. 1980 Jan;9(1):61-5. doi: 10.1111/j.1365-2125.1980.tb04798.x.
2
Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin.磺胺二甲氧嘧啶、阿莫西林、克拉维酸分别与阿莫西林或替卡西林联用、替莫西林及氯唑西林对脐血血清中胆红素的置换作用。
Br J Clin Pharmacol. 1985 Oct;20(4):345-8. doi: 10.1111/j.1365-2125.1985.tb05075.x.
3
Displacement of albumin-bound antimicrobial agents by bilirubin.胆红素对白蛋白结合型抗菌药物的置换作用。
Pharmacology. 1976;14(5):464-72. doi: 10.1159/000136629.
4
Bilirubin-displacing effect of furosemide and sulfisoxazole. An in vitro and in vivo study in neonatal serum.
Dev Pharmacol Ther. 1983;6(4):230-8. doi: 10.1159/000457309.
5
Drug distribution in whole blood of mothers and their newborn infants: studies of cloxacillin and flucloxacillin.母亲及其新生儿全血中的药物分布：氯唑西林和氟氯西林的研究。
Eur J Clin Pharmacol. 1982;22(4):351-8. doi: 10.1007/BF00548405.
6
7
Effect of penicillins on bilirubin-albumin binding.青霉素对胆红素-白蛋白结合的影响。
J Pediatr. 1988 Sep;113(3):566-8. doi: 10.1016/s0022-3476(88)80655-3.
8
Displacement of bilirubin from albumin by ibuprofen in vitro.布洛芬体外从白蛋白上置换胆红素。
Pediatr Res. 2010 Jun;67(6):614-8. doi: 10.1203/PDR.0b013e3181da7578.
9
The effect of paraben preservatives on albumin binding of bilirubin.对羟基苯甲酸酯类防腐剂对胆红素白蛋白结合的影响。
J Pediatr. 1976 Sep;89(3):475-8. doi: 10.1016/s0022-3476(76)80557-4.
10
The binding of isoxazolyl penicillins to human serum proteins.
Arzneimittelforschung. 1977;27(11):2136-8.
引用本文的文献
1
Differential transplacental binding of diazepam: causes and implications.地西泮经胎盘的差异结合：原因及影响
Eur J Clin Pharmacol. 1983;24(5):595-601. doi: 10.1007/BF00542207.
2
Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin.磺胺二甲氧嘧啶、阿莫西林、克拉维酸分别与阿莫西林或替卡西林联用、替莫西林及氯唑西林对脐血血清中胆红素的置换作用。
Br J Clin Pharmacol. 1985 Oct;20(4):345-8. doi: 10.1111/j.1365-2125.1985.tb05075.x.
3
Neonatal bilirubin toxicity. A review of kernicterus and the implications of drug-induced bilirubin displacement.新生儿胆红素毒性。核黄疸综述及药物诱导胆红素置换的影响。
Clin Pharmacokinet. 1987 Jul;13(1):26-50. doi: 10.2165/00003088-198713010-00002.
4
In vitro displacement of bilirubin by antibiotics and 2-hydroxybenzoylglycine in newborns.抗生素和2-羟基苯甲酰甘氨酸对新生儿胆红素的体外置换作用。
Antimicrob Agents Chemother. 1988 Oct;32(10):1571-5. doi: 10.1128/AAC.32.10.1571.
本文引用的文献
1
The dissociation of bilirubin from albumin and its clinical implications.胆红素与白蛋白的解离及其临床意义。
J Pediatr. 1959 Sep;55:268-79. doi: 10.1016/s0022-3476(59)80223-7.
2
3
Transfer of adsorbed bilirubin to specific binding proteins.吸附胆红素向特异性结合蛋白的转移。
Biochem J. 1970 Dec;120(4):19P. doi: 10.1042/bj1200019p.
4
The adsorption of bilirubin by Sephadex and its relationship to the criteria for exchange transfusion.胆红素在葡聚糖凝胶上的吸附作用及其与换血标准的关系。
Pediatrics. 1969 Oct;44(4):543-8.
5
6
Clinical significance of protein binding of the penicillins.青霉素蛋白结合的临床意义。
Ann N Y Acad Sci. 1967 Sep 27;145(2):282-90. doi: 10.1111/j.1749-6632.1967.tb50225.x.
7
[The place of determination of unbound bilirubin and serum albumin in the surveillance of jaundice in the premature infant].[未结合胆红素及血清白蛋白测定在早产儿黄疸监测中的地位]
Arch Fr Pediatr. 1974 Feb-Mar;31(2):201-13.
8
The effect of antimicrobial agents on bilirubin binding by human erythrocytes.抗菌剂对人红细胞胆红素结合的影响。
Scand J Clin Lab Invest. 1972 Nov;30(3):331-7. doi: 10.3109/00365517209084298.
9
Drug-protein binding. IV. Modulation of binding. Increasing activity of sulfonamides with displacing agents: a review.药物-蛋白质结合。IV. 结合的调节。用置换剂增强磺胺类药物的活性：综述。
Ann N Y Acad Sci. 1973 Nov 26;226:273-92. doi: 10.1111/j.1749-6632.1973.tb20490.x.
10
A new approach to the determination of protein-bound bilirubin displacement and its applications.
Ann N Y Acad Sci. 1973 Nov 26;226:238-46. doi: 10.1111/j.1749-6632.1973.tb20485.x.
Zotero 插件