磺胺二甲氧嘧啶、阿莫西林、克拉维酸分别与阿莫西林或替卡西林联用、替莫西林及氯唑西林对脐血血清中胆红素的置换作用。
Displacement of bilirubin from cord serum by sulphadimethoxine, amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin.
作者信息
Davies B E
出版信息
Br J Clin Pharmacol. 1985 Oct;20(4):345-8. doi: 10.1111/j.1365-2125.1985.tb05075.x.
Abstract
The displacement of bilirubin from its binding sites in cord serum by sulphadimethoxine and various penicillins was studied using Sephadex gel filtration. Sulphadimethoxine displaced bilirubin at concentrations well within the normal therapeutic range of sulphonamide concentrations. Amoxycillin, clavulanic acid in combination with either amoxycillin or ticarcillin, temocillin and cloxacillin displaced bilirubin at concentrations much higher than those found clinically. It was concluded that the primary binding site/s of sulphadimethoxine and the secondary binding site/s of the penicillins were at or near the primary bilirubin binding site.
摘要
使用葡聚糖凝胶过滤法研究了磺胺二甲氧嘧啶和各种青霉素从脐血血清中胆红素结合位点置换胆红素的情况。磺胺二甲氧嘧啶在磺胺类药物浓度的正常治疗范围内就能置换胆红素。阿莫西林、与阿莫西林或替卡西林联合使用的克拉维酸、替莫西林和氯唑西林在远高于临床发现的浓度时就能置换胆红素。得出的结论是，磺胺二甲氧嘧啶的主要结合位点和青霉素的次要结合位点位于主要胆红素结合位点或其附近。
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