卡比马唑口服给药后孕妇中甲巯咪唑的药代动力学。
The pharmacokinetics of methimazole in pregnant patients after oral administration of carbimazole.
作者信息
Skellern G G, Knight B I, Otter M, Low C K, Alexander W D
出版信息
Br J Clin Pharmacol. 1980 Feb;9(2):145-7. doi: 10.1111/j.1365-2125.1980.tb05824.x.
Abstract
1 A high performance liquid chromatographic (HPLC) method was used to study the pharmacokinetics of methimazole after oral administration of carbimazole to women in various stages of pregnancy. 2 In one patient it was possible to conduct the study in the first and third timesters: there was an appreciable increase in the apparent clearance of methimazole. 3 Based on the assumption of complete absorption and hydrolysis of carbimazole to methimazole the mean apparent clearance was found to be significantly higher in pregnant patients receiving 10 mg carbimazole than in non-pregnant patients receiving the same dose.
摘要
- 采用高效液相色谱（HPLC）法研究了卡比马唑口服给药后在不同孕期女性体内甲巯咪唑的药代动力学。2. 在一名患者中，分别在孕早期和孕晚期进行了该项研究：甲巯咪唑的表观清除率有明显升高。3. 基于卡比马唑完全吸收并水解为甲巯咪唑这一假设，发现接受10mg卡比马唑的孕妇中甲巯咪唑的平均表观清除率显著高于接受相同剂量的非孕妇。
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本文引用的文献
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