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Effects of systemic non-steroidal anti-inflammatory drugs on nociception during tail ischaemia and on reperfusion hyperalgesia in rats.全身性非甾体抗炎药对大鼠尾部缺血期间伤害感受及再灌注痛觉过敏的影响。
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本文引用的文献

1
Bradykinin.缓激肽
Am Heart J. 1963 Jan;65:116-23. doi: 10.1016/0002-8703(63)90221-7.
2
Experimental production of pain in man: sensitivity of a new method to 600 mg. of aspirin.
Clin Pharmacol Ther. 1969 Mar-Apr;10(2):213-6. doi: 10.1002/cpt1969102213.
3
Clinical trial comparing pentazocine with pethidine and morphine in severe ischaemic limb pain.
Br J Clin Pract. 1971 Jan;25(1):27-30.
4
The release of prostaglandin-like substances during reactive and functional hyperemia in the hind leg of the dog.
Pol J Pharmacol Pharm. 1974 Jan-Apr;26(1):167-70.
5
Pharmacological study on a new analgesic-anti-inflammatory drug: alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionic acid of K 4277.一种新型镇痛抗炎药K 4277（α-（4-（1-氧代-2-异吲哚啉基）-苯基）-丙酸）的药理学研究
Arzneimittelforschung. 1973 Aug;23(8):1100-7.
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New analgesic-anti-inflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives.
Arzneimittelforschung. 1973 Aug;23(8):1090-100. doi: 10.1002/chin.197344288.
7
Mild analgesics evaluated with the "Submaximum Effort Tourniquet Technique". II. The influence of a tranquilizer on their effect.
Psychopharmacologia. 1974;38(4):357-62. doi: 10.1007/BF00429134.
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Mild analgesics evaluated with the "Submaximum Effort Tourniquet Technique". I. The influence of psychological factors on their effect.
Psychopharmacologia. 1974;38(4):351-6. doi: 10.1007/BF00429133.
9
Comparative efficacy of ibuprofen and aspirin in episiotomy pain.
Clin Pharmacol Ther. 1974 Jun;15(6):565-70. doi: 10.1002/cpt1974156565.
10
Prostaglandin release by the isolated perfused rabbit heart.离体灌注兔心脏释放前列腺素
Prostaglandins. 1973 Apr;3(4):439-45. doi: 10.1016/0090-6980(73)90151-2.

病理性缺血性肌肉疼痛对镇痛药的反应。

Response of pathological ischaemic muscle pain to analgesics.

作者信息

Sacchetti G, Lampugnani R, Battistini C, Mandelli V

出版信息

Br J Clin Pharmacol. 1980 Feb;9(2):165-9. doi: 10.1111/j.1365-2125.1980.tb05828.x.

DOI:10.1111/j.1365-2125.1980.tb05828.x
PMID:7356905
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1429853/
Abstract

1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo. 2 Differences in pain intensity scored on a five-point scale were taken as measurement of pain relief. 3 This double-blind, cross-over trial showed that indoprofen had significantly greater analgesic effect than placebo and reference drug. 4 From a methodological point of view there are many arguments on favour of pathological ischaemic pain as a test for clinical assessment of analgesics.

摘要

  1. 24名因腿部慢性闭塞性动脉疾病而遭受剧痛的患者口服了吲哚美辛（200毫克）、布洛芬（300毫克）和安慰剂。

  2. 以五点量表对疼痛强度进行评分的差异作为疼痛缓解的衡量指标。

  3. 这项双盲交叉试验表明，吲哚美辛的镇痛效果明显优于安慰剂和对照药物。

  4. 从方法论的角度来看，有许多理由支持将病理性缺血性疼痛作为镇痛药临床评估的一项测试。