病理性缺血性肌肉疼痛对镇痛药的反应。
Response of pathological ischaemic muscle pain to analgesics.
作者信息
Sacchetti G, Lampugnani R, Battistini C, Mandelli V
出版信息
Br J Clin Pharmacol. 1980 Feb;9(2):165-9. doi: 10.1111/j.1365-2125.1980.tb05828.x.
Abstract
1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo. 2 Differences in pain intensity scored on a five-point scale were taken as measurement of pain relief. 3 This double-blind, cross-over trial showed that indoprofen had significantly greater analgesic effect than placebo and reference drug. 4 From a methodological point of view there are many arguments on favour of pathological ischaemic pain as a test for clinical assessment of analgesics.
摘要
24名因腿部慢性闭塞性动脉疾病而遭受剧痛的患者口服了吲哚美辛（200毫克）、布洛芬（300毫克）和安慰剂。
以五点量表对疼痛强度进行评分的差异作为疼痛缓解的衡量指标。
这项双盲交叉试验表明，吲哚美辛的镇痛效果明显优于安慰剂和对照药物。
从方法论的角度来看，有许多理由支持将病理性缺血性疼痛作为镇痛药临床评估的一项测试。
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