Warchoł T, Karoń H, Batko J
Acta Haematol Pol. 1978 Oct-Dec;9(4):243-7.
The activity of NADPH- and NADH-dependent erythrocyte glutathione reductase was determined in rats with Morris 5123 hepatoma at different stages of tumor development (10, 20, 30 and 40 days after transplantation). During the early stage of tumor growth the activity of glutathione reductase with either of these coenzymes was increased. In the late stage of the disease the activity of NADPH-dependent glutathione reductase fell below control values. The obtained results are discussed in the light of previous observations on the effects of this neoplasm on the metabolism of erythrocytes.
在移植后10、20、30和40天等不同肿瘤发展阶段，测定了患有Morris 5123肝癌的大鼠中依赖NADPH和NADH的红细胞谷胱甘肽还原酶活性。在肿瘤生长早期，这两种辅酶中的任何一种所依赖的谷胱甘肽还原酶活性均升高。在疾病后期，依赖NADPH的谷胱甘肽还原酶活性降至对照值以下。根据先前关于这种肿瘤对红细胞代谢影响的观察结果对所得结果进行了讨论。
