Gupta B L, Azam M, Baquer N Z
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Biochem Int. 1990;21(4):725-31.
Glutathione peroxidase and glutathione reductase activities were measured in erythrocytes from control, diabetic and insulin-treated diabetic rats. A significant decrease in the activity of glutathione peroxidase and an increase in the glutathione reductase activity were found with increase in the time of diabetes which may result in the alteration in the activity of the pentose phosphate pathway by the modulation of the levels of NADPH. Insulin administration reverses the change in the activity of glutathione peroxidase but does not reverse the glutathione reductase activity during diabetes. The overall changes may be due to changes in the levels of insulin, triiodothyronine and thyroxine.
在对照大鼠、糖尿病大鼠及胰岛素治疗的糖尿病大鼠的红细胞中测定了谷胱甘肽过氧化物酶和谷胱甘肽还原酶的活性。随着糖尿病病程延长，谷胱甘肽过氧化物酶活性显著降低，谷胱甘肽还原酶活性升高，这可能通过调节NADPH水平导致磷酸戊糖途径活性改变。糖尿病期间，胰岛素给药可逆转谷胱甘肽过氧化物酶活性的变化，但不能逆转谷胱甘肽还原酶活性。这些总体变化可能归因于胰岛素、三碘甲状腺原氨酸和甲状腺素水平的改变。
