镉诱导的骨碱性磷酸酶降低及其锌预防作用
Cadmium-induced reduction of bone alkaline phosphatase and its prevention by zinc.
作者信息
Bonner F W, King L J, Parke D V
出版信息
Chem Biol Interact. 1980 Mar;29(3):369-72. doi: 10.1016/0009-2797(80)90155-6.
PMID:7357680
Abstract
The dietary exposure of rats to cadmium (75 ppm) for periods of up to 48 weeks caused an accumulation of cadmium in the femur, and an inhibition of the accumulation of zinc in the bone. After 48 weeks of cadmium treatment, there was a decreased activity of alkaline phosphatase in the femur. This effect was prevented by a simultaneous dietary supplement of zinc (300 ppm).
摘要
大鼠饮食中接触镉（75 ppm）长达48周会导致镉在股骨中蓄积，并抑制锌在骨骼中的蓄积。镉处理48周后，股骨中碱性磷酸酶的活性降低。同时补充锌（300 ppm）可防止这种影响。
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