The urinary excretion of alkaline phosphatase after the repeated parenteral administration of cadmium to rats given a high dietary supplement of zinc.

Repeated parenteral administration of cadmium (Cd) (1.5 mg Cd2+/kg, daily for 28 days) produced an initial transitory (< 4 days) increase in the urinary excretion of alkaline phosphatase within 48 h: a second and persistent phase of enzymuria developed around day 15. Pretreatment and simultaneous administration of zinc (Zn) as a dietary supplement (2000 ppm Zn2+) abolished the initial phase of enzymuria but had no effect upon the second phase.