McCarthy D S, Ostrow D N, Hershfield E S
Chest. 1980 Apr;77(4):473-7. doi: 10.1378/chest.77.4.473.
The rapid development of irreversible airflow obstruction in two nonsmoking women who recovered from acute idiopathic pulmonary fibrosis is discussed. Pulmonary fibrosis was diagnosed clinically and by lung biopsy. Recovery both clinically and radiologically was complete. Several pulmonary function studies in both patients showed a typical restrictive pattern (reduced lung volumes and carbon dioxide diffusing capacity, normal FEV1/FVC ratio). Within one year both patients exhibited an obstructive pattern of dysfunction (hyperinflation, gas trapping, reduced airflow measurements). These patients illustrated irreversible airway obstruction following recovery from the restrictive stage of pulmonary fibrosis.
本文讨论了两名从急性特发性肺纤维化康复的非吸烟女性中不可逆气流阻塞的快速发展情况。通过临床诊断及肺活检确诊为肺纤维化。临床及影像学上均完全康复。两名患者的多项肺功能研究均显示典型的限制性模式（肺容积和二氧化碳弥散能力降低，FEV1/FVC比值正常）。在一年内，两名患者均表现出阻塞性功能障碍模式（肺过度充气、气体潴留、气流测量值降低）。这些患者说明了肺纤维化限制性阶段康复后出现的不可逆气道阻塞情况。
