Roussinov K S, Yonkov D I
Acta Physiol Pharmacol Bulg. 1978;4(2):30-5.
In experiments involving training of albino rats in a maze it has been found that strychnine (1 mg/kg) introduced 5 min before or immediately after training, improves learning and retention. Upon blocking of the central muscarine-sensitive cholinergic structures (scopolamine 2 mg/kg) and of the nicotine-sensitive structures (spasmolytin 20 mg/kg), the learning and memory facilitating effect of strychnine is not manifested. The realization of the learning and memory facilitating effect of strychnine requires optimum functional level of the activity of the central cholinergic system.
在涉及对白化大鼠进行迷宫训练的实验中发现，在训练前5分钟或训练后立即注射士的宁（1毫克/千克），可改善学习和记忆保持。当阻断中枢对毒蕈碱敏感的胆碱能结构（东莨菪碱2毫克/千克）和对烟碱敏感的结构（解痉素20毫克/千克）时，士的宁促进学习和记忆的作用未表现出来。士的宁促进学习和记忆作用的实现需要中枢胆碱能系统活动的最佳功能水平。
