Yonkov D, Roussinov K
Acta Physiol Pharmacol Bulg. 1979;5(1):41-6.
Diethyldithiocarbamate (DDC) introduced in a dose of 400 mg/kg 3 hours before training slightly deteriorates learning in albino rats in a maze. Upon testing 24 hours and 14 days after training, DDC is found to impair markedly the retention indices, when introduced both before and immediately after the end of the training. On the background of DDC, the stimulants caffeine, strychnine, amphetamine, echinopsine and centredrine do not manifest their typical memory-facilitating effect. According to data from the literature and from our previous experiments it is known that the DDC dose used lowers the noradrenaline level in the brain by more than 50 per cent. This suggests that the realization of the memory-facilitating effect of these central stimulants with different basic mechanisms of action requires optimum functional activity of the noradrenergic brain system, as well as this has been established in other experiments for the cholinergic system.
在训练前3小时以400毫克/千克的剂量引入二乙基二硫代氨基甲酸盐（DDC），会使白化大鼠在迷宫中的学习能力略有下降。在训练后24小时和14天进行测试时，发现无论是在训练前还是训练结束后立即引入DDC，都会显著损害记忆保持指标。在DDC的作用背景下，咖啡因、士的宁、苯丙胺、刺蒺藜碱和森特林等兴奋剂并未表现出其典型的促进记忆的作用。根据文献数据和我们之前的实验可知，所使用的DDC剂量可使大脑中的去甲肾上腺素水平降低50%以上。这表明，这些具有不同基本作用机制的中枢兴奋剂要实现促进记忆的作用，需要去甲肾上腺素能脑系统具有最佳的功能活性，就像在其他实验中已证实的胆碱能系统一样。
