Hermansen K, Christensen S E, Orskov H
Horm Metab Res. 1980 Jan;12(1):23-5. doi: 10.1055/s-2007-996187.
The influence of the Na+/K+ pump on somatostatin secretion from the isolated perfused canine pancreas was investigated. The somatostatin secretion was reversibly increased in response to addition of ouabain (10(-5) mol/l) and to omission of extracellular K+, procedures which are known to cause a blockade of the Na+/K+ pump. The stimulatory effect on somatostatin release was abolished during calcium depletion. The results suggest that the operation of the Na+/K+ pump plays an important role for the somatostatin secretion. The action of the Na+/K+ pump on the secretory function of the D-cells is dependent on the presence of extracellular calcium.
研究了钠钾泵对离体灌注犬胰腺生长抑素分泌的影响。加入哇巴因（10⁻⁵mol/L）以及去除细胞外钾离子（已知这两种操作会导致钠钾泵被阻断）后，生长抑素分泌可逆性增加。在无钙状态下，对生长抑素释放的刺激作用消失。结果表明，钠钾泵的运转对生长抑素分泌起重要作用。钠钾泵对D细胞分泌功能的作用依赖于细胞外钙的存在。
