Hermansen K, Christensen S E, Orskov H
Scand J Clin Lab Invest. 1979 Dec;39(8):717-22. doi: 10.3109/00365517909108162.
The effect of potassium on somatostatin secretion from the isolated perfused canine pancreas was studied. Potassium stimulated dose-dependent somatostatin release in a monophasic response pattern. The effect of potassium was abolished in the absence of calcium. Perfusion of 1 micronmol/l atropine and 1 micronmol/l propranolol was without effect on the potassium induced somatostatin release. The results suggest that the stimulatory effect of potassium on somatostatin release is secondary to increases in calcium influx into the D cell. The sympathetic and parasympathetic nerve endings in the pancreas are apparently not involved in the potassium mediated secretory processes.
研究了钾对离体灌注犬胰腺生长抑素分泌的影响。钾以单相反应模式刺激剂量依赖性生长抑素释放。在无钙的情况下，钾的作用消失。灌注1微摩尔/升阿托品和1微摩尔/升普萘洛尔对钾诱导的生长抑素释放无影响。结果表明，钾对生长抑素释放的刺激作用继发于进入D细胞的钙内流增加。胰腺中的交感和副交感神经末梢显然不参与钾介导的分泌过程。
