Herfert J, Wienker T F, Ropers H H
Hum Genet. 1980 Feb;53(2):271-3. doi: 10.1007/BF00273510.
The specific, receptor-dependent 5 alpha-dihydrotestosterone-binding capacity of cultured fibroblasts derived from genital and nongenital skin has been compared. With the methods employed, the detectable amount of the DHT receptor in nongenital skin-derived fibroblasts is variable, often approaching the limit of detectability. Therefore it is concluded that for differential diagnosis of disorders of sexual development, DHT-binding studies should be performed with genital skin fibroblasts only.
已对源自生殖器皮肤和非生殖器皮肤的培养成纤维细胞的特异性、受体依赖性5α-二氢睾酮结合能力进行了比较。采用这些方法，非生殖器皮肤来源的成纤维细胞中可检测到的双氢睾酮（DHT）受体量是可变的，常常接近可检测极限。因此得出结论，对于性发育障碍的鉴别诊断，仅应使用生殖器皮肤成纤维细胞进行DHT结合研究。
