Bohnenkamp B, Rhomberg W, Sonnentag W, Feldmann U
J Cancer Res Clin Oncol. 1980 Jan;96(1):105-14. doi: 10.1007/BF00412901.
Hundred nine unselected patients with metastatic renal cell carcinoma have been stratified into 3 groups according to their type of metastasis: 17 patients with sceletal involvement only, 67 patients with visceral metastases, and 21 patients with a mixed type of metastasis. Four patients with a locoregional pattern of recurrence were not included in the analysis. The survival data (evaluated by life table analysis and a modified Wilcoxon-Rang-test) revealed a better prognosis for patients presenting exclusively with osseous metastases compared to the group with visceral metastases. The patients with osseous metastases showed a median survival time from diagnosis of 29.9 months compared to 11.6 months in patients with visceral involvement. Considering only patients whose metastases have been detected after a period of latency post nephrectomy, there is a further increase in the survival in favour of the patients with sceletal metastases and the difference to the group with visceral metastases becomes statistically highly significant.
109例未经挑选的转移性肾细胞癌患者已根据转移类型分为3组：仅骨骼受累的患者17例，内脏转移的患者67例，以及混合型转移的患者21例。4例具有局部区域复发模式的患者未纳入分析。生存数据（通过生命表分析和改良的Wilcoxon秩和检验评估）显示，与内脏转移组相比，仅出现骨转移的患者预后更好。骨转移患者从诊断开始的中位生存时间为29.9个月，而内脏受累患者为11.6个月。仅考虑肾切除术后经过一段潜伏期才检测到转移的患者，骨骼转移患者的生存率进一步提高，与内脏转移组的差异在统计学上具有高度显著性。
