Andersen D B, Holub B J
J Nutr. 1980 Mar;110(3):488-95. doi: 10.1093/jn/110.3.488.
A nutritionally acceptable diet, with all nutrients at or above their known requirements, was found useful for studying the myoinositol-responsive lipid accumulation in young rats. Succinyl sulfathiazole supplementation of the diet was judged unnecessary to produce increases in the concentration of hepatic triglycerides (TG). The TG accumulation appeared to decrease somewhat after reaching maximal levels under conditions of myo-inositol deficiency in young rats, whereas the accumulation was not observed in older animals. Both young male and female rats responded to dietary myo-inositol when supplemented at a level similar to the level of myo-inositol in the human diet.
研究发现，一种营养可接受的饮食，其所有营养素达到或高于已知需求水平，有助于研究幼鼠中对肌醇有反应的脂质积累。饮食中添加琥珀酰磺胺噻唑被认为对于提高肝脏甘油三酯（TG）浓度并无必要。在幼鼠肌醇缺乏的条件下，甘油三酯积累在达到最高水平后似乎有所下降，而在成年动物中未观察到这种积累现象。当以与人类饮食中肌醇水平相似的水平补充膳食肌醇时，幼年雄性和雌性大鼠均有反应。
