Skinner W A, Fuhrmann F, Rutledge L C, Moussa M A, Schreck C E
J Pharm Sci. 1980 Feb;69(2):196-8. doi: 10.1002/jps.2600690221.
Numerous cyclic analogs of lactic acid were synthesized to ascertain whether they might act as agonists of antagonists of lactic acid, a known attractant for mosquitoes. These compounds were evaluated with an in vitro blood-feeding test system and an in vivo cloth test. Two of the compounds in the blood-feeding test system showed biphasic results, acting as attractants at low concentrations and as repellents at higher concentrations. Several compounds (III, V, VII, and X) repelled Aedes aegypti mosquitoes in the blood-feeding test system. However, in the in vivo cloth test system, only III repelled the mosquitoes significantly.
合成了许多乳酸的环状类似物，以确定它们是否可能作为乳酸的激动剂或拮抗剂，乳酸是已知的蚊子引诱剂。这些化合物通过体外吸血测试系统和体内布料测试进行评估。吸血测试系统中的两种化合物显示出双相结果，在低浓度下作为引诱剂，在高浓度下作为驱避剂。几种化合物（III、V、VII和X）在吸血测试系统中对埃及伊蚊具有驱避作用。然而，在体内布料测试系统中，只有III能显著驱避蚊子。
