Golikov A P, Vorob'ev V E, Abdrakhmanov V R, Stazhadze L L, Bogomolov V V
Kosm Biol Aviakosm Med. 1980 Jan-Feb;14(1):42-6.
The study of external respiration and acid-base equilibrium of blood of 35 test subjects exposed to 49-day head-down (-4 degrees) tilting and of 6 test subjects exposed to 182-day head-down (-4 degrees) tilting demonstrated a trend for a decrease in the respiration rate, lung ventilation, oxygen consumption, and a relative increase in the exhalation time. With respect to the arterialized blood gases, a significant decrease in PaO2, an increase in PaCO2 and in the O2 alveolar-arterial difference were seen during the 49-day head-down tilting. During the 182-day head-down tilting a further increase in the CO2 arterio-alveolar difference was noted. These changes suggest shifts of the ventilation-perfusion ration in the lungs and, probably, disturbances of central regulation of respiration induced by head-down tilting. During the recovery period the above changes diminished gradually and disappeared by the 14th and 30th day after the 49- and 182-day head-down tilting, respectively.
对35名接受49天头低位（-4度）倾斜的受试者和6名接受182天头低位（-4度）倾斜的受试者的外呼吸和血液酸碱平衡进行研究，结果显示呼吸频率、肺通气量、耗氧量呈下降趋势，呼气时间相对增加。关于动脉化血气，在49天头低位倾斜期间，PaO2显著降低，PaCO2、肺泡-动脉血氧分压差增加。在182天头低位倾斜期间，动脉-肺泡二氧化碳分压差进一步增加。这些变化表明肺部通气-灌注比值发生改变，并且可能是头低位倾斜引起呼吸中枢调节紊乱。在恢复期，上述变化逐渐减轻，在49天和182天头低位倾斜后分别于第14天和第30天消失。
