Baranov V M, Tikhonov M A, Matsnev E I, Volkov M Iu, Markin A S, Khaĭdakov K S
Kosm Biol Aviakosm Med. 1991 Sep-Oct;25(5):20-4.
Time course variations in the ventilation and gas exchange functions of the lungs, gas composition and acid-base equilibrium of blood were investigated in 22 male test subjects, aged 27-49 years, who were kept in the head-down position (-8 degrees) and rocked in parallel swings. The subjects susceptible to motion sickness developed lung hyperventilation and concomitant alveolar-arterial hypocapnia and respiratory alkalosis which may potentiate a symptom-complex of vestibular disorders. To control hypocapnia, the subjects used a hypercapnic breathing mixture (4% CO2, 96% air). This eliminated the above changes in the gas composition and acid-base equilibrium of blood, and in 7 out of 10 subjects alleviated vestibular symptoms and elongated the time of motion tolerance. In addition, the prophylactic effect of hypercapnic exposure showed individual variations which seem to be associated with individual sensitivity of the respiratory center to hypercapnic stimulation.
对22名年龄在27至49岁之间的男性受试者进行了研究，观察他们在头低位（-8度）并进行平行摆动时，肺部通气和气体交换功能、血液气体成分和酸碱平衡随时间的变化情况。易患晕动病的受试者出现肺过度通气，并伴有肺泡-动脉低碳酸血症和呼吸性碱中毒，这可能会加重前庭障碍的症状复合体。为了控制低碳酸血症，受试者使用了高碳酸呼吸混合气（4%二氧化碳，96%空气）。这消除了血液气体成分和酸碱平衡的上述变化，并且在10名受试者中有7名减轻了前庭症状并延长了运动耐受时间。此外，高碳酸暴露的预防效果存在个体差异，这似乎与呼吸中枢对高碳酸刺激的个体敏感性有关。
