Vinson G P, Whitehouse B J, Dell A, Etienne T, Morris H R
Nature. 1980 Apr 3;284(5755):464-7. doi: 10.1038/284464a0.
The secretion of aldosterone from the zona glomerulosa of the mammalian adrenal cortex is stimulated by ACTH, potassium, angiotensin II and III, growth hormone, serotonin and E series prostaglandins. Some experimental and clinical studies suggest that additional stimulants of the zona glomerulosa must exist, possibly including pituitary factors other than ACTH. The possibility that posterior pituitary extracts may contain a zona glomerulosa stimulant was first suggested 20 years ago, but has since received little attention. We describe here the purification from posterior pituitary extracts of activities that stimulate rat glomerulosa cells and whole tissue in vitro. One of the active compounds has been identified as alpha-MSH (melanocyte stimulating hormone).
哺乳动物肾上腺皮质球状带分泌醛固酮受促肾上腺皮质激素（ACTH）、钾、血管紧张素II和III、生长激素、血清素以及E系列前列腺素的刺激。一些实验和临床研究表明，必然存在其他刺激球状带的物质，可能包括除ACTH之外的垂体因子。20年前首次有人提出垂体后叶提取物可能含有刺激球状带的物质，但此后很少受到关注。我们在此描述从垂体后叶提取物中纯化出的在体外刺激大鼠球状带细胞和整个组织的活性物质。其中一种活性化合物已被鉴定为α-促黑素细胞激素（α-MSH）。
