Walton L A, Edelman D A, Fowler W C, Photopulos G J
Obstet Gynecol. 1980 Mar;55(3):353-7. doi: 10.1097/00006250-198003000-00017.
Cervical intraepithelial neoplasia (CIN) is so rampant that simpler, effective, and less costly methods of therapy are being evaluated to replace the aggressive surgical therapeutic measures of the past. Cryosurgery is one alternative method. A review is presented of 152 patients in the childbearing age group with biopsy confirmation of CIN II (moderate dysplasia) and CIN III (severe dysplasia and carcinoma in situ). The persistence of CIN 3 months after therapy was deemed a treatment failure. Initial failure rates (24.2% for CIN II and 31.6% for CIN III) were high by this stringent definition. However, follow-up smears, further treatment, and a review of the literature definition of "treatment failure" lowered the failure rate to acceptable levels such that cryosurgery should be utilized in the therapy of cervical intraepithelial neoplasia.
宫颈上皮内瘤变（CIN）非常普遍，因此人们正在评估更简单、有效且成本更低的治疗方法，以取代过去激进的手术治疗措施。冷冻手术是一种替代方法。本文回顾了152例育龄期患者，这些患者经活检确诊为CIN II（中度发育异常）和CIN III（重度发育异常和原位癌）。治疗3个月后CIN持续存在被视为治疗失败。按照这个严格的定义，初始失败率较高（CIN II为24.2%，CIN III为31.6%）。然而，后续涂片检查、进一步治疗以及对“治疗失败”文献定义的重新审视将失败率降低到了可接受的水平，因此冷冻手术应被用于宫颈上皮内瘤变的治疗。
