Potish R A
Radiology. 1980 Apr;135(1):219-21. doi: 10.1148/radiology.135.1.7360965.
In order to predict which patients have a high risk for radiation-related small-bowel damage, the concept of the dose-response curve was applied to the predisposing factors (number of previous laparotomies, extent of surgery, thin physique, hypertension, age, cancer stage, number of treatment days, fractionation, and weight change during radiotherapy) present in 92 patients receiving identical radiation doses and volumes. This analysis allows an estimate of the probability of complications to be assigned to individual patients. The utility and limitations of the dose-response concept are discussed.
为了预测哪些患者有发生放射性小肠损伤的高风险，剂量反应曲线的概念被应用于92名接受相同辐射剂量和体积的患者所存在的易感因素（既往剖腹手术次数、手术范围、体型消瘦、高血压、年龄、癌症分期、治疗天数、分割方式以及放疗期间体重变化）。该分析能够估计分配给个体患者的并发症概率。本文讨论了剂量反应概念的实用性和局限性。
