Potish R A
Am J Clin Oncol. 1982 Apr;5(2):189-94. doi: 10.1097/00000421-198204000-00068.
The importance of risk factors in the development of radiation-related enteric damage has been demonstrated. Ninety-two women with ovarian tumors received 2000 rads to the abdomen, followed by an additional 2975 rads to the pelvis. By analyzing the development of small bowel obstruction in these women and in other series from the literature, it appears that more than half of enteric complications can be attributed to factors such as prior surgery, thin physique, and preexisting vascular damage. These constitutional factors often will have a greater effect on the development of small bowel damage than will radiation dose, volume, or time. By taking such factors into account and by substituting alternative forms of therapy when feasible, morbidity secondary to radiotherapy can be substantially reduced.
风险因素在放射性肠损伤发生过程中的重要性已得到证实。92名患有卵巢肿瘤的女性接受了腹部2000拉德的辐射，随后盆腔又接受了2975拉德的辐射。通过分析这些女性以及文献中其他系列病例中小肠梗阻的发生情况，似乎超过一半的肠道并发症可归因于既往手术、体型消瘦和既往存在的血管损伤等因素。这些体质因素对小肠损伤发生的影响通常比辐射剂量、体积或时间更大。通过考虑这些因素并在可行时采用替代治疗方式，可以大幅降低放疗继发的发病率。
