哺乳期大鼠脑内的皮质酮：可能与垂体-肾上腺皮质对应激反应的减弱有关。
Brain corticosterone in lactating rats: possible relation to the attenuation of the pituitary-adrenocortical response to stress.
作者信息
Kakihana R, Moore J A, Butte J C
出版信息
Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):105-17.
In an attempt to elucidate the mechanism of suppression of the plasma corticosterone stress response in the lactating female rats, nonstress levels of corticosterone in plasma and hypothalamus, cerebral cortex, hippocampus and pituitaries were determined in the lactating and nonlactating Sprague-Dawley rats at 1600-1700 hr by the protein binding assay. The brain corticosterone levels were significantly higher (64-92%) in the lactating than in nonlactating rats, while the plasma corticosterone levels were identical. We conclude that the suppression of the stress response in the lactating female rats is directly or indirectly related to the high basal levels of corticosterone in the brain, which result from a chronic hyperactivation of the endocrine axis.
为了阐明哺乳期雌性大鼠血浆皮质酮应激反应受抑制的机制，采用蛋白质结合分析法，于1600 - 1700时测定了哺乳期和非哺乳期斯普拉格-道利大鼠血浆、下丘脑、大脑皮层、海马体和垂体中皮质酮的非应激水平。哺乳期大鼠脑内皮质酮水平显著高于非哺乳期大鼠（高64 - 92%），而血浆皮质酮水平相同。我们得出结论，哺乳期雌性大鼠应激反应的抑制与脑内皮质酮的高基础水平直接或间接相关，这是内分泌轴长期过度激活的结果。
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