Nuclear activation of carbon tetrachloride and chloroform.

Diaz Gomez M I, Castro J A

Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):191-4.

Highly purified rat liver nuclear preparations are able to activate anaerobically CCl4 and aerobically CHCl3 to reactive metabolites that bind to lipids and proteins. Activity in nuclear preparations is smaller than in microsomes but of the same order of magnitude.