Relationships between the pharmacokinetics of carbon tetrachloride conversion to carbon dioxide and chloroform and liver injury.
作者信息
Reynolds E S, Treinen R J, Farrish H H, Moslen M T
出版信息
Arch Toxicol Suppl. 1984;7:303-6. doi: 10.1007/978-3-642-69132-4_50.
PMID:6440512
Abstract
Rate and extent of CCl4 metabolism by pathways leading to CO2 and CHCl3 were evaluated by measuring the amounts of these metabolites exhaled during discrete intervals following six different doses of CCl4. Pulmonary pharmacokinetics of 14CO2 and CHCl3 exhalation after CCl4 administration were compared with those after Na214CO3 and 14CHCl3 administration. Exhalation of 14CO2 metabolite declined more rapidly than expected after hepatotoxic doses of CCl4. This decline could be due to injury associated changes in the metabolism of CCl4.
摘要
相似文献
1
Relationships between the pharmacokinetics of carbon tetrachloride conversion to carbon dioxide and chloroform and liver injury.
Arch Toxicol Suppl. 1984;7:303-6. doi: 10.1007/978-3-642-69132-4_50.
2
Metabolism of [14C]carbon tetrachloride to exhaled, excreted and bound metabolites. Dose-response, time-course and pharmacokinetics.
Biochem Pharmacol. 1984 Nov 1;33(21):3363-74. doi: 10.1016/0006-2952(84)90107-2.
3
Isopropanol enhancement of carbon tetrachloride metabolism in vivo.
Life Sci. 1982 Aug 16;31(7):661-9. doi: 10.1016/0024-3205(82)90767-6.
4
Effect of O2 tension on the bioactivation and metabolism of aliphatic halides by primary rat-hepatocyte cultures.
Xenobiotica. 1984 Jul;14(7):521-5. doi: 10.3109/00498258409151441.
5
Fasting increases the concentrations of carbon tetrachloride and of its metabolite chloroform in the liver of mice.
Toxicol Lett. 1983 May;16(3-4):231-4. doi: 10.1016/0378-4274(83)90181-9.
6
Mechanisms of chloroform and carbon tetrachloride toxicity in primary cultured mouse hepatocytes.
Environ Health Perspect. 1986 Nov;69:301-5. doi: 10.1289/ehp.8669301.
7
Nuclear activation of carbon tetrachloride and chloroform.
Res Commun Chem Pathol Pharmacol. 1980 Jan;27(1):191-4.
8
Dose- and route-dependent alterations in metabolism and toxicity of chemical compounds in ethanol-treated rats: difference between highly (chloroform) and poorly (carbon tetrachloride) metabolized hepatotoxic compounds.
Toxicol Appl Pharmacol. 1997 Jan;142(1):13-21. doi: 10.1006/taap.1996.8025.
9
Dichloroacetic acid pretreatment of male and female rats increases chloroform metabolism in vitro.
Toxicology. 1997 Dec 19;124(1):53-62. doi: 10.1016/s0300-483x(97)00132-7.
10
Biotransformation of carbon tetrachloride and lipid peroxidation promotion by liver nuclear preparations from different animal species.
Cancer Lett. 1990 Aug;53(1):9-15. doi: 10.1016/0304-3835(90)90004-h.
引用本文的文献
1
Volatile substance abuse.
Clin Rev Allergy Immunol. 1997 Fall;15(3):271-89. doi: 10.1007/BF02737701.
2
The role of acetylcysteine in clinical toxicology.
Med Toxicol. 1987 Mar-Apr;2(2):93-104. doi: 10.1007/BF03260008.
Zotero 插件