Swanson J M, Kinsbourne M
Science. 1980 Mar 28;207(4438):1485-7. doi: 10.1126/science.7361102.
Forty children were given a diet free of artificial food dyes and other additives for 5 days. Twenty of the children had been classified as hyperactive by scores on the Conners Rating Scale and were reported to have favorable responses to stimulant medication. A diagnosis of hyperactivity had been rejected in the other 20 children. Oral challenges with large doses (100 or 150 milligrams) of a blend of FD & C approved food dyes or placebo were administered on days 4 and 5 of the experiment. The performance of the hyperactive children on paired-associate learning tests on the day they received the dye blend was impaired relative to their performance after they received the placebo, but the performance of the nonhyperactive group was not affected by the challenge with the food dye blend.
40名儿童接受了为期5天不含人工食用色素和其他添加剂的饮食。其中20名儿童根据康纳斯评定量表的得分被归类为多动症患者，据报道他们对刺激性药物有良好反应。另外20名儿童的多动症诊断被否决。在实验的第4天和第5天，对这些儿童进行大剂量（100或150毫克）的FD&C批准的食用色素混合物或安慰剂的口服激发试验。多动症儿童在接受色素混合物当天的配对联想学习测试中的表现相对于接受安慰剂后的表现有所受损，但非多动症组的表现不受食用色素混合物激发试验的影响。
