Zigman S, Gilman P
Science. 1980 Apr 11;208(4440):188-91. doi: 10.1126/science.7361115.
A series of cyanine dyes used in photography, with reduction potentials from -1.35 to -0.20 volts, were tested for their ability to inhibit mitosis and cell growth in fertilized sea urchin eggs. Low concentrations of dyes with reduction potentials more negative than -1.0 volt generally inhibited mitosis and growth, whereas those with more positive reduction potentials did not. The active dyes penetrated the cell, entered all subcellular compartments, were bound to numerous macromolecules, and inhibited synthesis of macromolecules. Thus mitosis and growth may be retarded with substances that can alter electrochemical activity in cells.
一系列用于摄影的花青染料，其还原电位在-1.35至-0.20伏之间，被测试了抑制受精海胆卵有丝分裂和细胞生长的能力。还原电位比-1.0伏更负的低浓度染料通常会抑制有丝分裂和生长，而还原电位更正的染料则不会。活性染料穿透细胞，进入所有亚细胞区室，与众多大分子结合，并抑制大分子的合成。因此，有丝分裂和生长可能会被能够改变细胞电化学活性的物质所延缓。
