Stoklasová A, Krízala J, Ledvina M
Strahlentherapie. 1980 Mar;156(3):205-9.
The changes in the concentrations of total, nonprotein and protein SH-groups were spectrophotometrically determined in the small intestine and bone marrow of the rats 10, 20, 30 and 60 min after the administration of protective doses of cystamine (50 mg/kg), mexamine (10 mg/kg) or of a mixture of cystamine with mexamine (20 + 10 mg/kg). Cystamine caused an increase in the concentration of mainly nonprotein thiols, whereas the mexamine administration increased the protein SH-groups (mainly between the 20th and 30th min after treatment). The radioprotective mixture led to the most pronounced increase at the 10-min interval. This increase at the 10- and 20-min intervals was more pronounced (or identical) than after cystamine or mexamine administered as a single agent. If the SH-concentration should correspond to the degree of radioprotection, then the phenomenon observed would indicate the usefulness of the mixture administered.
在给予大鼠胱胺（50毫克/千克）、美沙明（10毫克/千克）或胱胺与美沙明混合物（20 + 10毫克/千克）的保护剂量后10、20、30和60分钟，用分光光度法测定大鼠小肠和骨髓中总巯基、非蛋白质巯基和蛋白质巯基浓度的变化。胱胺主要使非蛋白质硫醇浓度增加，而给予美沙明会使蛋白质巯基增加（主要在治疗后第20至30分钟之间）。辐射防护混合物在10分钟间隔时导致最明显的增加。在10和20分钟间隔时的这种增加比单独给予胱胺或美沙明更明显（或相同）。如果巯基浓度应与辐射防护程度相对应，那么观察到的现象将表明所给予混合物的有效性。
