[胃癌和消化性溃疡中白细胞对肿瘤及胚胎抗原的致敏作用]

[Leukocyte sensitization to tumor and embryonic antigens in gastric cancer and peptic ulcer].

作者信息

Shmakov A P, Novikov D K

出版信息

Vopr Onkol. 1980;26(2):7-12.

Abstract

The antigens (AG) of gastric cancer extracts would inhibit the migration of leucocytes in the culture with control serum in 6 among 7 (85%) patients with gastric cancer (GC) of stage I, in 8 of 10 (80%) patients -- stage II, in 24 of 43 (56%) patients-stage III, in 10 of 35 (28.5%) patients -- stage IV. The effect of autoplasma on the inhibition of leucocytes migration (ILM) of GC AG was varied. The mixture of extracts from several tumors suppressed more frequently the migration of leucocytes. The liver extracts antigens of a 10-week human embryo induced ILM in 29 of 49 (59%) patients with GC I--IV. The gastric mucosa antigens induced ILM in 21 of 95 (22%) patients GC I--IV. The migration of leucocytes in 13 of 110 (12%) control patients was suppressed by AG GC in the culture containing control serum. AG of human embryo liver induced ILM in 7 of 55 (13%) examined control patients, 5 of them having ulcerous disease. It is supposed that sensitization to embryonal antigens may procede malignant transformation of gastric ulcers.

摘要

胃癌提取物的抗原（AG）在含对照血清的培养物中，可抑制7例Ⅰ期胃癌（GC）患者中6例（85%）、10例Ⅱ期患者中8例（80%）、43例Ⅲ期患者中24例（56%）、35例Ⅳ期患者中10例（28.5%）的白细胞迁移。自身血浆对胃癌AG抑制白细胞迁移（ILM）的作用各不相同。几种肿瘤提取物的混合物更频繁地抑制白细胞迁移。10周龄人类胚胎肝脏提取物抗原在49例Ⅰ - Ⅳ期GC患者中的29例（59%）诱导了ILM。胃黏膜抗原在95例Ⅰ - Ⅳ期GC患者中的21例（22%）诱导了ILM。在含对照血清的培养物中，110例对照患者中有13例（12%）的白细胞迁移被胃癌AG抑制。人类胚胎肝脏AG在55例受检对照患者中的7例（13%）诱导了ILM，其中5例患有溃疡病。推测对胚胎抗原的致敏可能先于胃溃疡的恶性转化。