Dilts P V, Ahokas R A
Am J Obstet Gynecol. 1980 Apr 1;136(7):889-96. doi: 10.1016/0002-9378(80)91047-9.
In order to further understand the effects of ingested lead (Pb) on the fetus and the possible interaction of the trace element zinc (Zn) with Pb, groups of rats with dated pregnancies were fed 0, 10, 50, 100, 200 or 500 mg/L of Pb in water throughout pregnancy. Diet was provided ad libitum. A group pair fed with the 200 mg/L of Pb group and a group fed both Zn and Pb, 200 mg/L, were also studied. Placental weight remained constant, but cell division and total protein level were decreased while cell size increased markedly. Fetal carcass and liver weight, cell division, and protein were decrease while cell growth was unchanged. Brain weight decreased while cell division, growth, and protein were unchanged. Kidney weight, cell division and protein level were unchanged but cell growth was decreased. Organ dry weight varied with wet weight while the percentage of water was unchanged. Whether pair feeding and Zn supplements improve carcass and liver weight is questionabel.
为了进一步了解摄入的铅（Pb）对胎儿的影响以及微量元素锌（Zn）与铅的可能相互作用，将怀孕日期确定的大鼠组在整个孕期饮用含0、10、50、100、200或500mg/L铅的水。随意提供饮食。还研究了一组与200mg/L铅组配对喂食的大鼠以及一组同时喂食锌和200mg/L铅的大鼠。胎盘重量保持不变，但细胞分裂和总蛋白水平下降，而细胞大小显著增加。胎儿胴体和肝脏重量、细胞分裂和蛋白质减少，而细胞生长没有变化。脑重量下降，而细胞分裂、生长和蛋白质没有变化。肾脏重量、细胞分裂和蛋白质水平没有变化，但细胞生长下降。器官干重随湿重变化，而水分百分比没有变化。配对喂食和补充锌是否能改善胴体和肝脏重量尚不确定。
