Dilts P V, Ahokas R A
Am J Obstet Gynecol. 1979 Dec 1;135(7):940-6. doi: 10.1016/0002-9378(79)90820-2.
In order to further understand the effects of ingested Pb on pregnancy and the possible interaction of the trace element Zn with Pb, groups of dated pregnant rats were fed 10, 50, 100, 200, or 500 mg/L of Pb in water throughout pregnancy. A control group with no Pb, but diet ad lib, and a pair-fed control group with no Pb were also studied. Maternal average daily food consumption was significantly reduced at 50 mg/L of Pb and up. Total and net maternal weights were significantly reduced at 50 mg/L of Pb and up. Pair feeding at the 200 mg/L level improved maternal weight gain but not to control levels. Zn, 200 mg/L, supplement at the 200 mg/L of Pb level caused no improvement nor did ad lib diet with Pb removed after 16 days. Fetal weight decreased progressively as Pb levels were increased. Pair feeding at the 200 mg/L Pb of level and Zn, 200 mg/L, supplement with 200 mg/L of Pb significantly increased fetal weight but not to control levels. Placental weight was unchanged throughout. The results indicate that Pb-induced fetal growth retardation is due to reduced maternal food and energy intake, as well as to direct effect on the fetus. Excess dietary Zn improves fetal growth, probably by increasing maternal food consumption.
为了进一步了解摄入的铅对妊娠的影响以及微量元素锌与铅之间可能存在的相互作用，将怀孕不同天数的大鼠分为几组，在整个孕期通过饮水给予10、50、100、200或500mg/L的铅。还研究了一个不添加铅但自由进食的对照组和一个不添加铅的配对喂养对照组。铅浓度达到50mg/L及以上时，母体平均每日食物摄入量显著减少。铅浓度达到50mg/L及以上时，母体总重量和净重量显著降低。在200mg/L铅水平下进行配对喂养可改善母体体重增加，但未达到对照组水平。在200mg/L铅水平下补充200mg/L的锌并无改善作用，在16天后去除铅并自由进食也没有改善作用。随着铅水平的升高，胎儿体重逐渐下降。在200mg/L铅水平下进行配对喂养并补充200mg/L的锌可显著增加胎儿体重，但未达到对照组水平。胎盘重量在整个过程中保持不变。结果表明，铅诱导的胎儿生长迟缓是由于母体食物和能量摄入减少以及对胎儿的直接影响。过量的膳食锌可能通过增加母体食物摄入量来改善胎儿生长。
