Geddes L A, Bourland J D, Tacker W A
Am J Physiol. 1980 Feb;238(2):H231-6. doi: 10.1152/ajpheart.1980.238.2.H231.
The threshold energy and current required for ventricular defibrillation was determined in dogs ranging in weight from 6.4 to 38 kg and in ponies ranging in weight from 40 to 101 kg. Trapezoidal waves, 10 ms in duration, with 10%, 50%, 70%, and 90% tilt were applied to transchest electrodes. For all values of tilt, the energy and current required increased with body weight. The energy dose (joules per kilogram of body weight) was higher for the heavier animals, whereas the current dose (peak amperes per kilogram of body weight) was essentially the same for dogs and ponies. In both species and for all four waveforms, the percent success increased with increasing energy and current dose. For all four waveforms and for both species, the threshold average current required for defibrillation was between 0.38 and 0.48 A/kg, indicating that average current may be a convenient unit to compare the efficacy of different waveforms.
在体重6.4至38千克的犬类以及体重40至101千克的矮种马中，测定了心室除颤所需的阈值能量和电流。将持续时间为10毫秒、倾斜度分别为10%、50%、70%和90%的梯形波施加于经胸电极。对于所有倾斜度值，所需的能量和电流均随体重增加而增加。较重动物的能量剂量（每千克体重焦耳数）更高，而犬类和矮种马的电流剂量（每千克体重峰值安培数）基本相同。在这两个物种中，对于所有四种波形，成功百分比均随能量和电流剂量的增加而增加。对于所有四种波形以及两个物种，除颤所需的阈值平均电流在0.38至0.48安/千克之间，这表明平均电流可能是比较不同波形疗效的一个方便单位。
