Rogers D M, Herrington J L, Morton C
Ann Surg. 1980 Feb;191(2):153-6. doi: 10.1097/00000658-198002000-00004.
Despite the relative frequency of iatrogenic splenectomy, its effect on postoperative morbidity and mortality remains controversial. This retrospective study compares the postoperative morbidity and mortality among 72 patients who underwent a Nissen fundoplication for esophageal reflux and 25 patients who had iatrogenic splenectomy and Nissen fundoplication. The age range in both groups was comparable. In the Nissen fundoplication (N.F.) group the average postoperative hospital stay was 9.4 days and in the Nissen fundoplication and splenectomy (N.F. + S.) group postoperative hospital stay was 15 days. In the N.F. group nine patients (12.5%) experienced significant postoperative morbidity in comparison to 36% in the N.F. + S. group (statistically significant p less than 0.1%). In the later group the complications were of a more severe nature. No mortality occurred in the N.F. group and one patient died in the N.F. + S. group. Iatrogenic splenectomy in this patient could well have been a prime factor in precipitating his demise. This retrospective study stongly supports the view that iatrogenic splenectomy in association with Nissen fundoplication adds considerably to postoperative morbidity.
尽管医源性脾切除术相对常见,但其对术后发病率和死亡率的影响仍存在争议。这项回顾性研究比较了72例行尼森胃底折叠术治疗食管反流患者与25例行医源性脾切除术加尼森胃底折叠术患者的术后发病率和死亡率。两组的年龄范围相当。在尼森胃底折叠术(N.F.)组,术后平均住院时间为9.4天,而在尼森胃底折叠术加脾切除术(N.F. + S.)组,术后住院时间为15天。在N.F.组,9名患者(12.5%)出现了明显的术后并发症,而在N.F. + S.组这一比例为36%(p值小于0.1%,具有统计学意义)。在后一组中,并发症更为严重。N.F.组无死亡病例,而N.F. + S.组有1例患者死亡。该患者的医源性脾切除术很可能是导致其死亡的主要因素。这项回顾性研究有力地支持了这样一种观点,即与尼森胃底折叠术相关的医源性脾切除术会显著增加术后发病率。