Oster J R, Lanier D C, Vaamonde C A
Arch Intern Med. 1980 Apr;140(4):534-6.
Anatomical and functional renal medullary abnormalities are common in patients with sickle cell disease (HbSS) and sickle cell trait (HbAS). Sickle cell disease is associated with impaired urinary potassium excretion, but renal potassium handling in patients with HbAS has not been reported. To address this question, we gave nine HbAS and eight black control (HbAA) volunteers an oral potassium chloride load (0.75 mEq/kg of body weight), collected urine for five hours, and measured changes in the serum and urinay potassium levels. Both prior to and after potassium chloride loading, there were no differences between groups in serum or urinary potassium levels nor in percent of excretion of administered potassium. We conclude that patients with HbAS, despite decreased concentrating ability, have no impairment of the renal response to oral potassium loading and no apparent increased risk of hyperkalemia during periods of high potassium intake.
解剖学和功能性肾髓质异常在镰状细胞病（HbSS）和镰状细胞性状（HbAS）患者中很常见。镰状细胞病与尿钾排泄受损有关，但尚未报道HbAS患者的肾脏钾处理情况。为了解决这个问题，我们给9名HbAS志愿者和8名黑人对照（HbAA）志愿者口服氯化钾负荷（0.75 mEq/kg体重），收集5小时尿液，并测量血清和尿钾水平的变化。在氯化钾负荷前后，两组的血清或尿钾水平以及给予钾的排泄百分比均无差异。我们得出结论，尽管浓缩能力下降，但HbAS患者对口服钾负荷的肾脏反应没有受损，并且在高钾摄入期间没有明显增加的高钾血症风险。
