Anichkov N M
Arkh Patol. 1980;42(2):39-44.
A total of 477 transitional cell papillomas (TP) of the urinary bladder were divided into slowly (10.9%) and rapidly progressing (89.1%) ones according to the late results of the treatment and morbid anatomic features. Over a period of ten years following the excision of rapidly progressing TP the recurrencies were noted 5-fold and malignancies 12-fold as often comparatively to slowly progressing papillomas. Such papillomas were 1 cm and less in diameter and had a narrow base. The epithelial thickness reached 7--8 cell layers, and the mitotic index 3--4 fold surpassed the normal one (0.1%). The difference in histologic and ultrastructural differentiation of basal and intermediate cells of the epithelium persisted. Rapidly progressing TP were 0.5--2 cm in diameter, the epithelial thickness often exceeded that of 8 cell layers, while the mitotic index ranged within 0.5--1.0%. There were no sign of cellular atypia. The difference in histologic and ultrastructural differentiation of basal and imtermediate cells of the epithelium was in some cases effaced. TP subdivision into slowly and rapidly progressing papillomas will contribute to the improvement of the disease prognosis and statistical recording.
根据治疗的最终结果和病理解剖特征，总共477例膀胱移行细胞乳头状瘤（TP）被分为进展缓慢型（10.9%）和进展快速型（89.1%）。在切除进展快速型TP后的十年期间，复发率是进展缓慢型乳头状瘤的5倍，恶性变发生率是其12倍。这类乳头状瘤直径为1厘米及以下，基底狭窄。上皮厚度达7 - 8层细胞，有丝分裂指数比正常情况（0.1%）高出3 - 4倍。上皮基底细胞和中间细胞在组织学及超微结构分化上的差异依然存在。进展快速型TP直径为0.5 - 2厘米，上皮厚度常超过8层细胞，有丝分裂指数在0.5 - 1.0%范围内。未见细胞异型性迹象。上皮基底细胞和中间细胞在组织学及超微结构分化上的差异在某些情况下消失。将TP分为进展缓慢型和进展快速型乳头状瘤有助于改善疾病预后及统计记录。
