Oh T E, Turner C W, Ilett K F, Waterson J G, Paterson J W
Anaesth Intensive Care. 1978 Nov;6(4):322-7. doi: 10.1177/0310057X7800600405.
Droperidol is used in the anaesthetic management of pheochromocytoma because of its sedative, anti-dysrhythmic and alpha-adrenoreceptor blocking properties. However, droperidol when used in pheochromocytoma, has been reported to produce a paradoxical hypertensive response. In vitro experiments with perfused rabbit ear arteries using a histochemical fluorescence technique, showed droperidol to be an inhibitor of noradrenaline uptake into sympathetic nerve endings, and this uptake inhibition was dose related. The uptake inhibition effect did not, however, produce pressor changes in experiments simulating pheochromocytoma in cats. The hypertensive response to droperidol may be due to blockade of presynaptic alpha-adrenoreceptors and this possible mechanism of action is discussed.
氟哌利多因其镇静、抗心律失常和α-肾上腺素能受体阻断特性，被用于嗜铬细胞瘤的麻醉管理。然而，据报道，氟哌利多用于嗜铬细胞瘤时会产生反常的高血压反应。使用组织化学荧光技术对灌注兔耳动脉进行的体外实验表明，氟哌利多是去甲肾上腺素摄取到交感神经末梢的抑制剂，且这种摄取抑制与剂量相关。然而，在模拟猫嗜铬细胞瘤的实验中，摄取抑制作用并未产生升压变化。氟哌利多引起的高血压反应可能是由于突触前α-肾上腺素能受体的阻断，本文对此可能的作用机制进行了讨论。
