Chaves J M, Herrara E
Biol Neonate. 1980;37(3-4):172-9. doi: 10.1159/000241270.
Pregnant rats at 12 and 21 days of gestation and their virgin controls were injected intravenously with U-14C-glycerol and decapitated 1, 3, or 10 min later. The conversion of labelled glycerol to 14C-glucose was augmented in the 21-day pregnant rats. The disappearance of the newly formed 14C-glucuse from blood was faster in both 12- and 21-day pregnant rats than in their controls, being partially retained as liver 14C-glycogen. The greatest amount of radioactivity in all tissues appeared in the carcass hydrosoluble fraction. This amount was smaller in the pregnant rats. The reduced utilization of glycerol by extrahepatic tissues allowed the 21-day pregnant rats to dispose a greater amount of this substrate for gluconeogenesis.
妊娠12天和21天的孕鼠及其未孕对照鼠经静脉注射U-14C-甘油，1、3或10分钟后断头处死。在妊娠21天的孕鼠中，标记甘油向14C-葡萄糖的转化增加。在妊娠12天和21天的孕鼠中，新形成的14C-葡萄糖从血液中的消失速度均比其对照鼠快，部分以肝脏14C-糖原的形式保留。所有组织中放射性最强的部分出现在胴体水溶性部分。孕鼠体内的这一量较少。肝外组织对甘油利用的减少使妊娠21天的孕鼠能够将更多的这种底物用于糖异生。
